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Goat Anti-NOXA Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-NOXA Antibody AF2179a
    AF2179a (0.03 µg/ml) staining of Human Cerebellum lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q13794
Other Accession NP_066950, 5366
Reactivity Human
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 6030 Da
Additional Information
Gene ID 5366
Other Names Phorbol-12-myristate-13-acetate-induced protein 1, PMA-induced protein 1, Immediate-early-response protein APR, Protein Noxa, PMAIP1, NOXA
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-NOXA Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms NOXA
Function Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.
Cellular Location Mitochondrion
Tissue Location Highly expressed in adult T-cell leukemia cell line
Research Areas
Citations (0)

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A p38(MAPK)/HIF-1 pathway initiated by UVB irradiation is required to induce Noxa and apoptosis of human keratinocytes. Nys K, et al. J Invest Dermatol, 2010 Sep. PMID 20393480.
Perturbation of the Bcl-2 network and an induced Noxa/Bcl-xL interaction trigger mitochondrial dysfunction after DNA damage. Lopez H, et al. J Biol Chem, 2010 May 14. PMID 20223826.
The role of glucocorticoid receptor phosphorylation in Mcl-1 and NOXA gene expression. Lynch JT, et al. Mol Cancer, 2010 Feb 15. PMID 20156337.
Noxa is necessary for hydrogen peroxide-induced caspase-dependent cell death. Aikawa T, et al. FEBS Lett, 2010 Feb 19. PMID 20085765.
The anti-apoptotic protein BCL2L1/Bcl-xL is neutralized by pro-apoptotic PMAIP1/Noxa in neuroblastoma, thereby determining bortezomib sensitivity independent of prosurvival MCL1 expression. Hagenbuchner J, et al. J Biol Chem, 2010 Mar 5. PMID 20051518.

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$ 325.00
Cat# AF2179a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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