|Application ||WB, E|
|Other Accession||NP_066950, 5366|
|Calculated MW||6030 Da|
|Other Names||Phorbol-12-myristate-13-acetate-induced protein 1, PMA-induced protein 1, Immediate-early-response protein APR, Protein Noxa, PMAIP1, NOXA|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-NOXA Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.|
|Tissue Location||Highly expressed in adult T-cell leukemia cell line|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
A p38(MAPK)/HIF-1 pathway initiated by UVB irradiation is required to induce Noxa and apoptosis of human keratinocytes. Nys K, et al. J Invest Dermatol, 2010 Sep. PMID 20393480.
Perturbation of the Bcl-2 network and an induced Noxa/Bcl-xL interaction trigger mitochondrial dysfunction after DNA damage. Lopez H, et al. J Biol Chem, 2010 May 14. PMID 20223826.
The role of glucocorticoid receptor phosphorylation in Mcl-1 and NOXA gene expression. Lynch JT, et al. Mol Cancer, 2010 Feb 15. PMID 20156337.
Noxa is necessary for hydrogen peroxide-induced caspase-dependent cell death. Aikawa T, et al. FEBS Lett, 2010 Feb 19. PMID 20085765.
The anti-apoptotic protein BCL2L1/Bcl-xL is neutralized by pro-apoptotic PMAIP1/Noxa in neuroblastoma, thereby determining bortezomib sensitivity independent of prosurvival MCL1 expression. Hagenbuchner J, et al. J Biol Chem, 2010 Mar 5. PMID 20051518.
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