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Goat Anti-TRPM5 / MTR1 Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-TRPM5 / MTR1 Antibody AF2180a
    AF2180a (1 µg/ml) staining of Human Pancreas lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9NZQ8
Other Accession NP_055370, 29850, 56843 (mouse), 365391 (rat)
Reactivity Human, Mouse, Rat
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 131451 Da
Additional Information
Gene ID 29850
Other Names Transient receptor potential cation channel subfamily M member 5, Long transient receptor potential channel 5, LTrpC-5, LTrpC5, MLSN1- and TRP-related gene 1 protein, TRPM5 (HGNC:14323)
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-TRPM5 / MTR1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRPM5 (HGNC:14323)
Function Voltage-modulated Ca(2+)-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent- specific, non-selective cation channel that mediates the transport of Na(+), K(+) and Cs(+) ions equally well. Activated directly by increases in intracellular Ca(2+), but is impermeable to it. Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca(2+). Also activated by a fast intracellular Ca(2+) increase in response to inositol 1,4,5- triphosphate-producing receptor agonists. The channel is blocked by extracellular acidification. External acidification has 2 effects, a fast reversible block of the current and a slower irreversible enhancement of current inactivation. Is a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. Heat activation is due to a shift of the voltage- dependent activation curve to negative potentials. Activated by arachidonic acid in vitro. May be involved in perception of bitter, sweet and umami tastes. May also be involved in sensing semiochemicals.
Cellular Location Cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8TD43, ECO:0000255}
Tissue Location Strongly expressed in fetal brain, liver and kidney, and in adult prostate, testis, ovary, colon and peripheral blood leukocytes. Also expressed in a large proportion of Wilms' tumors and rhabdomyosarcomas. In monochromosomal cell lines shows exclusive paternal expression.
Research Areas
Citations (0)

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Association between common variation in genes encoding sweet taste signaling components and human sucrose perception. Fushan AA, et al. Chem Senses, 2010 Sep. PMID 20660057.
Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. Hosgood HD 3rd, et al. Occup Environ Med, 2009 Dec. PMID 19773279.
TRPM5 and taste transduction. Liman ER. Handb Exp Pharmacol, 2007. PMID 17217064.
International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. Clapham DE, et al. Pharmacol Rev, 2005 Dec. PMID 16382100.
Extracellular acid block and acid-enhanced inactivation of the Ca2+-activated cation channel TRPM5 involve residues in the S3-S4 and S5-S6 extracellular domains. Liu D, et al. J Biol Chem, 2005 May 27. PMID 15731110.

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$ 325.00
Cat# AF2180a
(40 western blots)
Availability: 7-10 days
Bulk Size
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