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Goat Anti-TRPC4AP Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-TRPC4AP Antibody AF2184a
    AF2184a (1 µg/ml) staining of U937 lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8TEL6
Other Accession NP_955400, 26133
Reactivity Human
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 90852 Da
Additional Information
Gene ID 26133
Other Names Short transient receptor potential channel 4-associated protein, Trp4-associated protein, Trpc4-associated protein, Protein TAP1, TNF-receptor ubiquitous scaffolding/signaling protein, Protein TRUSS, TRPC4AP, C20orf188, TRRP4AP
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-TRPC4AP Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms C20orf188, TRRP4AP
Function Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRUSS) complex specifically mediates the polyubiquitination and subsequent degradation of MYC. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1.
Research Areas
Citations (0)

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Myc protein is stabilized by suppression of a novel E3 ligase complex in cancer cells. Choi SH, et al. Genes Dev, 2010 Jun 15. PMID 20551172.
The frequency of the TRPC4AP haplotype in Alzheimer's patients. Poduslo SE, et al. Neurosci Lett, 2009 Feb 6. PMID 19059308.
Genome screen of late-onset Alzheimer's extended pedigrees identifies TRPC4AP by haplotype analysis. Poduslo SE, et al. Am J Med Genet B Neuropsychiatr Genet, 2009 Jan 5. PMID 18449908.
Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery. Angers S, et al. Nature, 2006 Oct 5. PMID 16964240.
TRUSS, a tumor necrosis factor receptor-1-interacting protein, activates c-Jun NH(2)-terminal kinase and transcription factor AP-1. Soond SM, et al. FEBS Lett, 2006 Aug 21. PMID 16876162.

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$ 325.00
Cat# AF2184a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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