|Application ||WB, E|
|Other Accession||NP_955400, 26133|
|Calculated MW||90852 Da|
|Other Names||Short transient receptor potential channel 4-associated protein, Trp4-associated protein, Trpc4-associated protein, Protein TAP1, TNF-receptor ubiquitous scaffolding/signaling protein, Protein TRUSS, TRPC4AP, C20orf188, TRRP4AP|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-TRPC4AP Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRUSS) complex specifically mediates the polyubiquitination and subsequent degradation of MYC. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Myc protein is stabilized by suppression of a novel E3 ligase complex in cancer cells. Choi SH, et al. Genes Dev, 2010 Jun 15. PMID 20551172.
The frequency of the TRPC4AP haplotype in Alzheimer's patients. Poduslo SE, et al. Neurosci Lett, 2009 Feb 6. PMID 19059308.
Genome screen of late-onset Alzheimer's extended pedigrees identifies TRPC4AP by haplotype analysis. Poduslo SE, et al. Am J Med Genet B Neuropsychiatr Genet, 2009 Jan 5. PMID 18449908.
Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery. Angers S, et al. Nature, 2006 Oct 5. PMID 16964240.
TRUSS, a tumor necrosis factor receptor-1-interacting protein, activates c-Jun NH(2)-terminal kinase and transcription factor AP-1. Soond SM, et al. FEBS Lett, 2006 Aug 21. PMID 16876162.
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