|Application ||WB, E|
|Other Accession||NP_003477, 8140|
|Calculated MW||55010 Da|
|Other Names||Large neutral amino acids transporter small subunit 1, 4F2 light chain, 4F2 LC, 4F2LC, CD98 light chain, Integral membrane protein E16, L-type amino acid transporter 1, hLAT1, Solute carrier family 7 member 5, y+ system cationic amino acid transporter, SLC7A5, CD98LC, LAT1, MPE16|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-LAT1 / SLC7A5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CD98LC, LAT1, MPE16|
|Function||Sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Involved in cellular amino acid uptake. Acts as an amino acid exchanger. Involved in the transport of L-DOPA across the blood- brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Plays a role in neuronal cell proliferation (neurogenesis) in brain. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L- nitrosocysteine (L-CNSO) across the transmembrane. May play an important role in high-grade gliomas. Mediates blood-to-retina L- leucine transport across the inner blood-retinal barrier which in turn may play a key role in maintaining large neutral amino acids as well as neurotransmitters in the neural retina. Acts as the major transporter of tyrosine in fibroblasts.|
|Cellular Location||Cytoplasm, cytosol. Apical cell membrane; Multi-pass membrane protein. Note=Located to the plasma membrane by SLC3A2/4F2hc. Localized to the apical membrane of placental syncytiophoblastic cells. Expressed in both luminal and abluminal membranes of brain capillary endothelial cells (By similarity)|
|Tissue Location||Expressed abundantly in adult lung, liver, brain, skeletal muscle, placenta, bone marrow, testis, resting lymphocytes and monocytes, and in fetal liver. Weaker expression in thymus, cornea, retina, peripheral leukocytes, spleen, kidney, colon and lymph node. During gestation, expression in the placenta was significantly stronger at full-term than at the mid-trimester stage. Also expressed in all human tumor cell lines tested and in the astrocytic process of primary astrocytic gliomas. Expressed in retinal endothelial cells and in the intestinal epithelial cell line Caco-2.|
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Provided below are standard protocols that you may find useful for product applications.
Impact of system L amino acid transporter 1 (LAT1) on proliferation of human ovarian cancer cells: a possible target for combination therapy with anti-proliferative aminopeptidase inhibitors. Fan X, et al. Biochem Pharmacol, 2010 Sep 15. PMID 20510678.
Properties of L-type amino acid transporter 1 in epidermal ovarian cancer. Kaji M, et al. Int J Gynecol Cancer, 2010 Apr. PMID 20375792.
CD98 expression is associated with poor prognosis in resected non-small-cell lung cancer with lymph node metastases. Kaira K, et al. Ann Surg Oncol, 2009 Dec. PMID 19777189.
L-type amino acid transporter 1 expression is a prognostic marker in patients with surgically resected stage I non-small cell lung cancer. Imai H, et al. Histopathology, 2009 Jun. PMID 19635099.
LAT1 expression in non-small-cell lung carcinomas: analyses by semiquantitative reverse transcription-PCR (237 cases) and immunohistochemistry (295 cases). Takeuchi K, et al. Lung Cancer, 2010 Apr. PMID 19559497.
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