|Application ||WB, E|
|Other Accession||NP_006450, 10613|
|Calculated MW||38926 Da|
|Other Names||Erlin-1, Endoplasmic reticulum lipid raft-associated protein 1, Protein KE04, Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1, SPFH domain-containing protein 1, ERLIN1, C10orf69, KE04, KEO4, SPFH1|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-KEO4 / ERLIN1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||C10orf69, KE04, KEO4, SPFH1|
|Function||Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex (PubMed:24217618).|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass type II membrane protein. Note=Associated with lipid raft-like domains of the endoplasmic reticulum membrane|
|Tissue Location||Expressed in heart, placenta, liver, kidney, pancreas, prostate, testis, ovary and small intestine|
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Provided below are standard protocols that you may find useful for product applications.
Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia. Martins-de-Souza D, et al. J Psychiatr Res, 2010 May 14. PMID 20471030.
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
SPFH1 and SPFH2 mediate the ubiquitination and degradation of inositol 1,4,5-trisphosphate receptors in muscarinic receptor-expressing HeLa cells. Wang Y, et al. Biochim Biophys Acta, 2009 Nov. PMID 19751772.
An endoplasmic reticulum (ER) membrane complex composed of SPFH1 and SPFH2 mediates the ER-associated degradation of inositol 1,4,5-trisphosphate receptors. Pearce MM, et al. J Biol Chem, 2009 Apr 17. PMID 19240031.
Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes. Yuan X, et al. Am J Hum Genet, 2008 Oct. PMID 18940312.
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