|Application ||WB, E|
|Other Accession||NP_002623, 5228|
|Calculated MW||24789 Da|
|Other Names||Placenta growth factor, PlGF, PGF, PGFL, PLGF|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-PLGF Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth.|
|Cellular Location||Secreted. Note=The three isoforms are secreted but PlGF-2 appears to remain cell attached unless released by heparin|
|Tissue Location||While the three isoforms are present in most placental tissues, PlGF-2 is specific to early (8 week) placenta and only PlGF-1 is found in the colon and mammary carcinomas|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). Romero R, et al. Am J Obstet Gynecol, 2010 Jul 29. PMID 20673868.
Nuclear expression of FLT1 and its ligand PGF in FUS-DDIT3 carrying myxoid liposarcomas suggests the existence of an intracrine signaling loop. Andersson MK, et al. BMC Cancer, 2010 Jun 1. PMID 20515481.
First-trimester placental growth factor as a marker for hypertensive disorders and SGA. Cowans NJ, et al. Prenat Diagn, 2010 Jun. PMID 20509158.
Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. Romero R, et al. Am J Obstet Gynecol, 2010 May. PMID 20452482.
Elevated serum placenta growth factor (PlGF) levels in patients with systemic sclerosis: a possible role in the development of skin but not lung fibrosis. Hamaguchi Y, et al. J Dermatol Sci, 2010 Jun. PMID 20451352.
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