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AAK1 AntibodyPeptide-affinity purified goat antibody
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AF2198a | 0.1mg 400 ul | 7-10 days | $ 325.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
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- Backgrounds
AAK1 Antibody - Product info | |
| Other Accession | NP_055726 |
| Reactivity | Bovine, Human, Mouse, Rat |
| Concentration | 100ug/200ul |
| Isotype | IgG |
AAK1 Antibody - Additional info | |
| Other Names adaptor-associated kinase 1, MGC164570, MGC164568, MGC138170, KIAA1048, FLJ45252, FLJ42882, FLJ31060, FLJ25931, FLJ23712, DKFZp686K16132, DKFZp686F03202, AP2 associated kinase 1, AAK1; AAK1 | |
| Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions AAK1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. | |
AAK1 Antibody - Application data
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AF2198a (1 µg/ml) staining of Human Amygdala lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
AAK1 Antibody - Related products
AP7861a: AAK1 Antibody (N-term)
AP7861b: AAK1 Antibody (C-term)
LY11651a: AAK1 Over-expression Lysate
BP7861a: AAK1 Antibody (N-term) Blocking Peptide
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BACKGROUND
Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. This gene encodes a member of the SNF1 subfamily of Ser/Thr protein kinases. The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
REFERENCES
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614. Genomewide association study for onset age in Parkinson disease. Latourelle JC, et al. BMC Med Genet, 2009 Sep 22. PMID 19772629. Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348. A novel AAK1 splice variant functions at multiple steps of the endocytic pathway. Henderson DM, et al. Mol Biol Cell, 2007 Jul. PMID 17494869. Endocytic Ark/Prk kinases play a critical role in adriamycin resistance in both yeast and mammalian cells. Takahashi T, et al. Cancer Res, 2006 Dec 15. PMID 17178891.
