|Application ||WB, E|
|Other Accession||NP_658986, 128674, 192649 (rat)|
|Calculated MW||43996 Da|
|Other Names||Prokineticin receptor 2, PK-R2, G-protein coupled receptor 73-like 1, GPR73b, GPRg2, PROKR2, GPR73L1, PKR2|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-PROKR2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for prokineticin 2. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Expressed in the ileocecum, thyroid gland, pituitary gland, salivary gland, adrenal gland, testis, ovary and brain|
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Provided below are standard protocols that you may find useful for product applications.
Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor for prokineticins. The encoded protein is similar in sequence to GPR73, another G protein-coupled receptor for prokineticins.
PROKR2 is associated with methamphetamine dependence in the Japanese population. Kishi T, et al. Prog Neuropsychopharmacol Biol Psychiatry, 2010 Aug 16. PMID 20576534.
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
Divergent roles of prokineticin receptors in the endothelial cells: angiogenesis and fenestration. Guilini C, et al. Am J Physiol Heart Circ Physiol, 2010 Mar. PMID 20023120.
A comparative phenotypic study of kallmann syndrome patients carrying monoallelic and biallelic mutations in the prokineticin 2 or prokineticin receptor 2 genes. Sarfati J, et al. J Clin Endocrinol Metab, 2010 Feb. PMID 20022991.
Possible association of prokineticin 2 receptor gene (PROKR2) with mood disorders in the Japanese population. Kishi T, et al. Neuromolecular Med, 2009. PMID 19544013.
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