|Application ||WB, IHC, E|
|Other Accession||NP_740721, 3781, 140492 (mouse), 54262 (rat)|
|Predicted||Mouse, Rat, Dog, Cow|
|Calculated MW||63760 Da|
|Other Names||Small conductance calcium-activated potassium channel protein 2, SK2, SKCa 2, SKCa2, KCa2.2, KCNN2|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-KCNN2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed in atrial myocytes (at protein level). Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. Two transcript variants encoding different isoforms have been found for this gene.
Alpha-actinin2 cytoskeletal protein is required for the functional membrane localization of a Ca2+-activated K+ channel (SK2 channel). Lu L, et al. Proc Natl Acad Sci U S A, 2009 Oct 27. PMID 19815520.
Ablation of a Ca2+-activated K+ channel (SK2 channel) results in action potential prolongation in atrial myocytes and atrial fibrillation. Li N, et al. J Physiol, 2009 Mar 1. PMID 19139040.
Cell-cycle-dependent regulation of Ca2+-activated K+ channel in Jurkat T-lymphocyte. Morimoto T, et al. J Pharmacol Sci, 2007 May. PMID 17452806.
Molecular coupling of a Ca2+-activated K+ channel to L-type Ca2+ channels via alpha-actinin2. Lu L, et al. Circ Res, 2007 Jan 5. PMID 17110593.
Ca2+-activated K+ channels in human melanoma cells are up-regulated by hypoxia involving hypoxia-inducible factor-1alpha and the von Hippel-Lindau protein. Tajima N, et al. J Physiol, 2006 Mar 1. PMID 16396931.
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