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Goat Anti-DTX3 Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-DTX3 Antibody AF2213a
    AF2213a (0.3 µg/ml) staining of NIH3T3 lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8N9I9
Other Accession NP_848597, 196403, 80904 (mouse), 500847 (rat)
Reactivity Mouse
Predicted Human, Rat, Cow
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 37988 Da
Additional Information
Gene ID 196403
Other Names Probable E3 ubiquitin-protein ligase DTX3, 6.3.2.-, Protein deltex-3, Deltex3, RING finger protein 154, DTX3, RNF154
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-DTX3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DTX3
Synonyms RNF154
Function Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context (By similarity). Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
Cellular Location Cytoplasm.
Research Areas
Citations (0)

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DTX3 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).


Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains. Chastagner P, et al. EMBO Rep, 2006 Nov. PMID 17028573.
Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039.
The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity. Takeyama K, et al. J Biol Chem, 2003 Jun 13. PMID 12670957.
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932.
Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis. Kishi N, et al. Int J Dev Neurosci, 2001 Feb. PMID 11226752.

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$ 325.00
Cat# AF2213a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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