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Goat Anti-PINX1 (aa225-237) Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-PINX1 (aa225-237) Antibody AF2216a
    AF2216a (0.3 µg/ml) staining of HepG2 lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q96BK5
Other Accession NP_060354, 54984
Reactivity Human
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 37035 Da
Additional Information
Gene ID 54984
Other Names PIN2/TERF1-interacting telomerase inhibitor 1, Liver-related putative tumor suppressor, Pin2-interacting protein X1, Protein 67-11-3, TRF1-interacting protein 1, PINX1, LPTL, LPTS
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-PINX1 (aa225-237) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PINX1
Synonyms LPTL, LPTS
Function Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor.
Cellular Location Nucleus. Nucleus, nucleolus. Chromosome, telomere. Chromosome, centromere, kinetochore. Note=Localizes in nucleoli, at telomere speckles and to the outer plate of kinetochores. Localization to the kinetochore is mediated by its central region and depends on NDC80 and CENPE
Tissue Location Ubiquitous; expressed at low levels. Not detectable in a number of hepatocarcinoma cell lines
Research Areas
Citations (0)

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C-terminal amino acids 290-328 of LPTS/PinX1 confer telomerase inhibition. Chen G, et al. Biochem Biophys Res Commun, 2010 Aug 6. PMID 20620128.
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
Decreased expression of PinX1 protein is correlated with tumor development and is a new independent poor prognostic factor in ovarian carcinoma. Cai MY, et al. Cancer Sci, 2010 Jun. PMID 20367640.
Multiple genetic variants in telomere pathway genes and breast cancer risk. Shen J, et al. Cancer Epidemiol Biomarkers Prev, 2010 Jan. PMID 20056641.
PinX1 is a novel microtubule-binding protein essential for accurate chromosome segregation. Yuan K, et al. J Biol Chem, 2009 Aug 21. PMID 19553660.

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$ 325.00
Cat# AF2216a
(40 western blots)
Availability: 7-10 days
Bulk Size
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