Goat Anti-A4GNT / alpha4GNT Antibody
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q9UNA3 |
Other Accession | NP_057245, 51146 |
Reactivity | Human |
Predicted | Dog, Cow |
Host | Goat |
Clonality | Polyclonal |
Concentration | 100ug/200ul |
Isotype | IgG |
Calculated MW | 39497 Da |
Gene ID | 51146 |
---|---|
Other Names | Alpha-1, 4-N-acetylglucosaminyltransferase, Alpha4GnT, 2.4.1.-, A4GNT |
Format | 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Goat Anti-A4GNT / alpha4GNT Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | A4GNT |
---|---|
Function | Catalyzes the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans (PubMed:10430883). Necessary for the synthesis of type III mucin which is specifically produced in the stomach, duodenum, and pancreatic duct (PubMed:10430883). May protect against inflammation-associated gastric adenocarcinomas (By similarity). |
Cellular Location | Golgi apparatus membrane; Single- pass type II membrane protein |
Tissue Location | Detected in stomach and pancreas. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein from the glycosyltransferase 32 family. The enzyme catalyzes the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans. It forms a unique glycan, GlcNAcalpha1-->4Galbeta-->R and is largely associated with the Golgi apparatus membrane.
References
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
Genetic variation in a4GnT in relation to Helicobacter pylori serology and gastric cancer risk. Zheng Z, et al. Helicobacter, 2009 Oct. PMID 19751437.
Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348.
Clinical utility of quantitative RT-PCR targeted to alpha1,4-N-acetylglucosaminyltransferase mRNA for detection of pancreatic cancer. Ishizone S, et al. Cancer Sci, 2006 Feb. PMID 16441422.
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.
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