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SNX1 AntibodyPeptide-affinity purified goat antibody
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AF2230a | 0.1mg 400 ul | 7-10 days | $ 325.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
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- Backgrounds
SNX1 Antibody - Product info | |
| Other Accession | NP_690039 |
| Reactivity | Bovine, Human, Mouse, Rat |
| Concentration | 100ug/200ul |
| Isotype | IgG |
SNX1 Antibody - Additional info | |
| Other Names SNX1 | |
| Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions SNX1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. | |
SNX1 Antibody - Application data
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AF2230a (1 µg/ml) staining of HeLa lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
SNX1 Antibody - Related products
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BACKGROUND
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to lysosomes. This protein may form oligomeric complexes with family members. This gene results in three transcript variants encoding distinct isoforms.
REFERENCES
Regulation of P2Y1 receptor traffic by sorting Nexin 1 is retromer independent. Nisar S, et al. Traffic, 2010 Apr. PMID 20070609. SNX1 defines an early endosomal recycling exit for sortilin and mannose 6-phosphate receptors. Mari M, et al. Traffic, 2008 Mar. PMID 18088323. EGF induces macropinocytosis and SNX1-modulated recycling of E-cadherin. Bryant DM, et al. J Cell Sci, 2007 May 15. PMID 17502486. Sorting nexin 1 down-regulation promotes colon tumorigenesis. Nguyen LN, et al. Clin Cancer Res, 2006 Dec 1. PMID 17145813. Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors. Rojas R, et al. Mol Cell Biol, 2007 Feb. PMID 17101778.
