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PDE4B Antibody (C-Term)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q07343 |
| Other Accession | NP_002591.2, NP_001032416.1, NP_001032417.1, 5142, 18578 (mouse) |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 83343 Da |
| Gene ID | 5142 |
|---|---|
| Other Names | cAMP-specific 3', 5'-cyclic phosphodiesterase 4B, 3.1.4.53, DPDE4, PDE32, PDE4B, DPDE4 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PDE4B Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PDE4B (HGNC:8781) |
|---|---|
| Synonyms | DPDE4 |
| Function | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:15260978). May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents. |
| Cellular Location | [Isoform PDE4B5]: Cytoplasm. Cell membrane |
| Tissue Location | Expressed in brain, heart, lung and skeletal muscle (PubMed:17519386). Expressed in white blood cells (PubMed:8392015) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognize all reported isoforms (NP_002591.2; NP_001032416.1; NP_001032417.1).
References
Gene set enrichment analysis unveils the mechanism for the phosphodiesterase 4B control of glucocorticoid response in B-cell lymphoma. Kim SW, Rai D, Aguiar RC. Clin Cancer Res. 2011 Nov 1;17(21):6723-32. PMID: 21742807
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