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ZCCHC11 / PAPD3 Antibody (C-Term)

Peptide-affinity purified goat antibody

  • IHC - ZCCHC11 / PAPD3 Antibody (C-Term) AF2236a
    AF2236a (4 µg/ml) staining of paraffin embedded Human Lymph Node. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q5TAX3
Other Accession NP_001009881.1, NP_056084.1, NP_001009882.1, 23318
Reactivity Human
Predicted Mouse, Rat, Dog, Cow
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 185166 Da
Additional Information
Gene ID 23318
Other Names Terminal uridylyltransferase 4, TUTase 4,, Zinc finger CCHC domain-containing protein 11, ZCCHC11, KIAA0191, TUT4
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsZCCHC11 / PAPD3 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ZCCHC11
Synonyms KIAA0191, TUT4
Function Uridylyltransferase that acts as a suppressor of microRNA (miRNA) biogenesis by specifically mediating the terminal uridylation of some miRNAs. Catalyzes the 3' uridylation of precursor let-7 (pre-let-7), a miRNA precursor. Uridylated pre- let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cells and is required for ES cells to maintain pluripotency. Does not bind RNA by itself, recruited to pre-let-7 miRNAs via its interaction with LIN28A and LIN28B. Also catalyzes the 3' uridylation of miR-26A, a miRNA that represses IL6 transcript, leading to abrogate IL6 transcript repression and promote cytokine expression. May also suppress Toll-like receptor-induced NF-kappa-B activity via binding to T2BP. Does not play a role in replication-dependent histone mRNA degradation.
Cellular Location Nucleus. Cytoplasm. Note=Translocates into the cytoplasm following treatment of the cell with LPS
Research Areas
Citations (0)

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This antibody is expected to recognize all 3 reported isoforms (as represented by NP_001009881.1; NP_056084.1; NP_001009882.1)


A novel Zinc finger protein, ZCCHC11, interacts with TIFA and modulates TLR signaling. Minoda Y, Saeki K, Aki D, Takaki H, Sanada T, Koga K, Kobayashi T, Takaesu G, Yoshimura A. Biochem Biophys Res Commun. 2006 Jun 9;344(3):1023-30.; Erratum
in: Biochem Biophys Res Commun. 2007 Feb 23;353(4):1121. PMID: 16643855

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$ 325.00
Cat# AF2236a
(40 western blots)
Availability: 7-10 days
Bulk Size
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