|Application ||WB, E|
|Other Accession||NP_005091.2, NP_653080.1, 9590|
|Calculated MW||191482 Da|
|Other Names||A-kinase anchor protein 12, AKAP-12, A-kinase anchor protein 250 kDa, AKAP 250, Gravin, Myasthenia gravis autoantigen, AKAP12, AKAP250|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||AKAP12 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC).|
|Cellular Location||Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Membrane; Lipid-anchor. Note=May be part of the cortical cytoskeleton|
|Tissue Location||Expressed in endothelial cells, cultured fibroblasts and osteosarcoma, but not in platelets, leukocytes, monocytic cell lines or peripherical blood cells|
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Provided below are standard protocols that you may find useful for product applications.
This anrtibody is expected to recognize both reported isoforms.
Gravin, an autoantigen recognized by serum from myasthenia gravis patients, is a kinase scaffold protein. Nauert JB, Klauck TM, Langeberg LK, Scott JD. Curr Biol. 1997 Jan 1;7(1):52-62. PMID: 9000000
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