|Application ||WB, IHC, E|
|Other Accession||NP_064520.2, NP_569079.1, 56897|
|Predicted||Mouse, Rat, Dog, Cow|
|Calculated MW||72133 Da|
|Other Names||ATPase WRNIP1, 188.8.131.52, Werner helicase-interacting protein 1, WRNIP1 (HGNC:20876)|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||WHIP / WRNIP1 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased. Plays also a role in the innate immune defense against viruses. Stabilizes the RIG-I/DDX58 dsRNA interaction and promotes RIG-I/DDX58 'Lys-63'-linked polyubiquitination. In turn, RIG-I/DDX58 transmits the signal through mitochondrial MAVS.|
|Cellular Location||Nucleus. Cytoplasm. Note=Colocalizes with WRN in granular structures in the nucleus|
|Tissue Location||Ubiquitously expressed.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognise isoform 1 (NP_064520.2) and isoform 2 (NP_569079.1).
A novel protein interacts with the Werner's syndrome gene product physically
and functionally. Kawabe Yi, Branzei D, Hayashi T, Suzuki H, Masuko T, Onoda F, Heo SJ, Ikeda H, Shimamoto A, Furuichi Y, Seki M, Enomoto T. J Biol Chem. 2001 Jun 8;276(23):20364-9. Epub 2001 Apr 11. PMID: 11301316
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