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MTMR9 (C Terminus) Antibody (C-Term)

Peptide-affinity purified goat antibody

     
  • IHC - MTMR9 (C Terminus) Antibody (C-Term) AF2246a
    EB05189 (5ug/ml) staining of paraffin embedded Rat Spleen. Steamed antigen retrieval with citrate buffer pH 6, DAB-staining.
    detail
  • IF - MTMR9 (C Terminus) Antibody (C-Term) AF2246a
    EB05189 Immunofluorescence analysis of paraformaldehyde fixed A549 cells, permeabilized with 0.15% Triton. Primary incubation 1hr (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml), showing cytoplasmic and Endoplasmic reticulum staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml).
    detail
  • IF - MTMR9 (C Terminus) Antibody (C-Term) AF2246a
    EB05189 Immunofluorescence analysis of paraformaldehyde fixed U2OS cells, permeabilized with 0.15% Triton. Primary incubation 1hr (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml), showing cytoplasmic and Endoplasmic reticulum staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml).
    detail
  • FC - MTMR9 (C Terminus) Antibody (C-Term) AF2246a
    EB05189 Flow cytometric analysis of paraformaldehyde fixed A549 cells (blue line), permeabilized with 0.5% Triton. Primary incubation 1hr (10ug/ml) followed by Alexa Fluor 488 secondary antibody (1ug/ml). IgG control: Unimmunized goat IgG (black line) followed by Alexa Fluor 488 secondary antibody.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC, E
Primary Accession Q96QG7
Other Accession NP_056273.2, 66036
Reactivity Rat
Predicted Human, Mouse, Pig, Dog, Cow
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 63462 Da
Additional Information
Gene ID 66036
Other Names Myotubularin-related protein 9, MTMR9, C8orf9, MTMR8
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMTMR9 (C Terminus) Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MTMR9
Synonyms C8orf9, MTMR8
Function Acts as an adapter for myotubularin-related phosphatases (PubMed:19038970, PubMed:22647598). Increases lipid phosphatase MTMR6 catalytic activity, specifically towards phosphatidylinositol 3,5- bisphosphate and MTMR6 binding affinity for phosphorylated phosphatidylinositols (PubMed:19038970, PubMed:22647598). Positively regulates lipid phosphatase MTMR7 catalytic activity (By similarity). Increases MTMR8 catalytic activity towards phosphatidylinositol 3- phosphate (PubMed:22647598). The formation of the MTMR6-MTMR9 complex, stabilizes both MTMR6 and MTMR9 protein levels (PubMed:19038970). Stabilizes MTMR8 protein levels (PubMed:22647598). Plays a role in the late stages of macropinocytosis possibly by regulating MTMR6-mediated dephosphorylation of phosphatidylinositol 3-phosphate in membrane ruffles (PubMed:24591580). Negatively regulates autophagy, in part via its association with MTMR8 (PubMed:22647598). Negatively regulates DNA damage-induced apoptosis, in part via its association with MTMR6 (PubMed:19038970, PubMed:22647598). Does not bind mono-, di- and tri- phosphorylated phosphatidylinositols, phosphatidic acid and phosphatidylserine (PubMed:19038970).
Cellular Location Cytoplasm. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:Q9Z2D0}; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, perinuclear region Endoplasmic reticulum. Note=Localizes to ruffles during EGF-induced macropinocytosis (By similarity) Colocalizes with MTMR6 to the perinuclear region (PubMed:19038970) Partially localizes to the endoplasmic reticulum (PubMed:19038970) {ECO:0000250|UniProtKB:Q9Z2D0, ECO:0000269|PubMed:19038970}
Tissue Location Expressed in many tissues.
Research Areas
Citations (0)
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References

Identification and localization of a new human myotubularin-related protein gene, mtmr8, on 8p22-p23. Appel S, Reichwald K, Zimmermann W, Reis A, Rosenthal A, Hennies HC. Genomics. 2001 Jul;75(1-3):6-8. PMID: 11472061

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$ 341.00
Cat# AF2246a
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