|Other Accession||NP_067028.1, 58480|
|Calculated MW||28218 Da|
|Other Names||Rho-related GTP-binding protein RhoU, CDC42-like GTPase 1, GTP-binding protein-like 1, Rho GTPase-like protein ARHU, Ryu GTPase, Wnt-1 responsive Cdc42 homolog 1, WRCH-1, RHOU (HGNC:17794)|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ARHU / WRCH1 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP- bound. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.|
|Cellular Location||Cell membrane; Lipid- anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor. Cell junction, focal adhesion. Cell projection, podosome. Note=Localizes to podosomes in SRC- transformed cells.|
|Tissue Location||Ubiquitously expressed in all tissues examined. Expressed at high levels in the stomach, small intestine, brain, skeletal muscle and placenta|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1. Tao W, Pennica D, Xu L, Kalejta RF, Levine AJ. Genes Dev. 2001 Jul 15;15(14):1796-807. PMID: 11459829
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