|Application ||WB, E|
|Other Accession||NP_006083.1, 10392|
|Predicted||Mouse, Rat, Pig, Dog, Cow|
|Calculated MW||107691 Da|
|Other Names||Nucleotide-binding oligomerization domain-containing protein 1, Caspase recruitment domain-containing protein 4, NOD1, CARD4|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NOD1 / CARD4 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Enhances caspase-9-mediated apoptosis. Induces NF-kappa- B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIPK2 dependent NF-kappa-B signaling pathway activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2 and OspB. Recruits NLRP10 to the cell membrane following bacterial infection.|
|Cellular Location||Cytoplasm. Cell membrane. Apical cell membrane. Basolateral cell membrane. Note=Detected in the cytoplasm and at the cell membrane. Following bacterial infection, localizes to bacterial entry sites in the cell membrane. Recruited to the basolateral and apical membranes in polarized epithelial cells|
|Tissue Location||Highly expressed in adult heart, skeletal muscle, pancreas, spleen and ovary. Also detected in placenta, lung, liver, kidney, thymus, testis, small intestine and colon|
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of NOD1 (CARD4) insertion/deletion polymorphism with susceptibility to IBD: a
meta-analysis. Lu WG, Zou YF, Feng XL, Yuan FL, Gu YL, Li X, Li CW, Jin C, Li JP. World J Gastroenterol. 2010 Sep 14;16(34):4348-56. PMID: 20818820
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