|Application ||IHC, E|
|Other Accession||NP_004545.2, NP_001185894.1, NP_001185895.1, NP_001185896.1, 4776|
|Predicted||Mouse, Rat, Pig, Dog|
|Calculated MW||95449 Da|
|Other Names||Nuclear factor of activated T-cells, cytoplasmic 4, NF-ATc4, NFATc4, T-cell transcription factor NFAT3, NF-AT3, NFATC4, NFAT3|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NFATC4 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 and IL- 4. Transcriptionally repressed by estrogen receptors; this inhibition is further enhanced by estrogen. Increases the transcriptional activity of PPARG and has a direct role in adipocyte differentiation. May play an important role in myotube differentiation. May play a critical role in cardiac development and hypertrophy. May play a role in deafferentation-induced apoptosis of sensory neurons.|
|Cellular Location||Cytoplasm. Nucleus. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals The subcellular localization of NFATC plays a key role in the regulation of gene transcription|
|Tissue Location||Highly expressed in placenta, lung, kidney, testis and ovary. Weakly expressed in spleen and thymus. Not expressed in peripheral blood lymphocytes. Detected in hippocampus.|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognise isoform 2, 3, 4 and 5 (NP_004545.2; NP_001185894.1; NP_001185895.1; NP_001185896.1 respectively).
Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins. Hoey T, Sun YL, Williamson K, Xu X. Immunity 1995 May;2(5):461-72 PMID: 7749981
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