|Other Accession||NP_056109.1, 4591|
|Predicted||Human, Dog, Cow|
|Calculated MW||107906 Da|
|Other Names||E3 ubiquitin-protein ligase TRIM37, 6.3.2.-, Mulibrey nanism protein, Tripartite motif-containing protein 37, TRIM37 (HGNC:7523)|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TRIM37 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||E3 ubiquitin-protein ligase required to prevent centriole reduplication (PubMed:15885686, PubMed:23769972). Probably acts by ubiquitinating positive regulators of centriole reduplication (PubMed:23769972). Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042). Has anti-HIV activity (PubMed:24317724).|
|Cellular Location||Cytoplasm, perinuclear region. Peroxisome. Note=Found in vesicles of the peroxisome. Aggregates as aggresomes, a perinuclear region where certain misfolded or aggregated proteins are sequestered for proteasomal degradation.|
|Tissue Location||Ubiquitous (PubMed:10888877). Highly expressed in testis, while it is weakly expressed in other tissues (PubMed:16310976).|
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Provided below are standard protocols that you may find useful for product applications.
Reported variants represent identical protein (NP_056109.1; NP_001005207.1).
Gene encoding a new RING-B-box-Coiled-coil protein is mutated in mulibrey nanism. Avela K, Lipsanen-Nyman M, Idanheimo N, Seemanova E, Rosengren S, Makela TP, Perheentupa J, Chapelle AD, Lehesjoki AE. Nat Genet. 2000 Jul;25(3):298-301. PMID: 10888877
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