|Application ||WB, IHC, E|
|Other Accession||NP_057632.2, NP_808800.1, 51280|
|Calculated MW||45333 Da|
|Other Names||Golgi membrane protein 1, Golgi membrane protein GP73, Golgi phosphoprotein 2, GOLM1, C9orf155, GOLPH2|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GOLPH2 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Unknown. Cellular response protein to viral infection.|
|Cellular Location||Golgi apparatus, cis-Golgi network membrane; Single-pass type II membrane protein. Note=Early Golgi. Cycles via the cell surface and endosomes upon lumenal pH disruption|
|Tissue Location||Widely expressed. Highly expressed in colon, prostate, trachea and stomach. Expressed at lower level in testis, muscle, lymphoid tissues, white blood cells and spleen Predominantly expressed by cells of the epithelial lineage Expressed at low level in normal liver. Expression significantly increases in virus (HBV, HCV) infected liver. Expression does not increase in liver disease due to non-viral causes (alcohol-induced liver disease, autoimmune hepatitis). Increased expression in hepatocytes appears to be a general feature of advanced liver disease. In liver tissue from patients with adult giant-cell hepatitis (GCH), it is strongly expressed in hepatocytes-derived syncytial giant cells. Constitutively expressed by biliary epithelial cells but not by hepatocytes|
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Provided below are standard protocols that you may find useful for product applications.
Both variants (NP_057632.2; NP_808800.1) encode the same isoform
GP73, a novel Golgi-localized protein upregulated by viral infection. Kladney RD, Bulla GA, Guo L, Mason AL, Tollefson AE, Simon DJ, Koutoubi Z, Fimmel CJ. Gene. 2000 May 16;249(1-2):53-65. PMID: 10831838
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