|Other Accession||NP_056250.3, NP_904355.1, 25897|
|Predicted||Human, Pig, Dog, Cow|
|Calculated MW||90696 Da|
|Other Names||E3 ubiquitin-protein ligase RNF19A, 6.3.2.-, Double ring-finger protein, Dorfin, RING finger protein 19A, p38, RNF19A, RNF19|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DORFIN / RNF19 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection.|
|Cellular Location||Membrane; Multi-pass membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Present in the hyaline inclusion bodies specifically found in motor neurons from amyotrophic lateral sclerosis patients. Present in the Lewy bodies specifically found in neurons from Parkinson disease patients|
|Tissue Location||Widely expressed, with highest levels in heart. Ubiquitously expressed in the central nervous system|
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Provided below are standard protocols that you may find useful for product applications.
Both variants (NP_056250.3; NP_904355.1) encode the same protein.
A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity. Niwa J, Ishigaki S, Doyu M, Suzuki T, Tanaka K, Sobue G. Biochem Biophys Res Commun. 2001 Mar 2;281(3):706-13. PMID: 11237715
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