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DORFIN / RNF19 Antibody (C-Term)

Peptide-affinity purified goat antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9NV58
Other Accession NP_056250.3, NP_904355.1, 25897
Predicted Human, Pig, Dog, Cow
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 90696 Da
Additional Information
Gene ID 25897
Other Names E3 ubiquitin-protein ligase RNF19A, 6.3.2.-, Double ring-finger protein, Dorfin, RING finger protein 19A, p38, RNF19A, RNF19
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDORFIN / RNF19 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RNF19A
Synonyms RNF19
Function E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection.
Cellular Location Membrane; Multi-pass membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Present in the hyaline inclusion bodies specifically found in motor neurons from amyotrophic lateral sclerosis patients. Present in the Lewy bodies specifically found in neurons from Parkinson disease patients
Tissue Location Widely expressed, with highest levels in heart. Ubiquitously expressed in the central nervous system
Research Areas
Citations (0)

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Both variants (NP_056250.3; NP_904355.1) encode the same protein.


A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity. Niwa J, Ishigaki S, Doyu M, Suzuki T, Tanaka K, Sobue G. Biochem Biophys Res Commun. 2001 Mar 2;281(3):706-13. PMID: 11237715

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$ 325.00
Cat# AF2287a
(40 western blots)
Availability: 7-10 days
Bulk Size
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