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SOCS5 Antibody (N-Term)

Peptide-affinity purified goat antibody

  • WB - SOCS5 Antibody (N-Term) AF2291a
    AF2291a (0.3 µg/ml) staining of Molt4 lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O75159
Other Accession NP_054730.1, 9655, 56468 (mouse)
Reactivity Human
Predicted Mouse, Rat, Pig, Cow
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 61246 Da
Additional Information
Gene ID 9655
Other Names Suppressor of cytokine signaling 5, SOCS-5, Cytokine-inducible SH2 protein 6, CIS-6, Cytokine-inducible SH2-containing protein 5, SOCS5, CIS6, CISH5, CISH6, KIAA0671
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSOCS5 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SOCS5
Synonyms CIS6, CISH5, CISH6, KIAA0671
Function SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling.
Research Areas
Citations (0)

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Both reported variants represent identical protein: NP_054730.1 and NP_659198.1.


Cloning and expression of CIS6, chromosome assignment to 3p22 and 2p21 by in situ hybridization. Magrangeas F, Apiou F, Denis S, Weidle U, Jacques Y, Minvielle S. Cytogenet Cell Genet. 2000;88(1-2):78-81. PMID: 10773671

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$ 325.00
Cat# AF2291a
(40 western blots)
Availability: 7-10 days
Bulk Size
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