|Application ||IHC, E|
|Other Accession||NP_065733.2, 57412|
|Calculated MW||41748 Da|
|Other Names||Arsenite methyltransferase, 22.214.171.124, Methylarsonite methyltransferase, S-adenosyl-L-methionine:arsenic(III) methyltransferase, AS3MT, CYT19|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Cyt19 / AS3MT Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me- AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
A novel S-adenosyl-L-methionine:arsenic(III) methyltransferase from rat liver cytosol. Lin S, Shi Q, Nix FB, Styblo M, Beck MA, Herbin-Davis KM, Hall LL, Simeonsson JB, Thomas DJ. J Biol Chem. 2002 Mar 29;277(13):10795-803. PMID: 11790780
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