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GCIP / MAID Antibody (C-Term)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC, E |
|---|---|
| Primary Accession | O95273 |
| Other Accession | NP_036274.3, NP_411241.1, 23582 |
| Reactivity | Human |
| Predicted | Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 40262 Da |
| Gene ID | 23582 |
|---|---|
| Other Names | Cyclin-D1-binding protein 1, Grap2 and cyclin-D-interacting protein, Human homolog of Maid, CCNDBP1, DIP1, GCIP, HHM |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GCIP / MAID Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CCNDBP1 |
|---|---|
| Synonyms | DIP1, GCIP, HHM |
| Function | May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F-dependent transcription. |
| Cellular Location | Cytoplasm. Nucleus. |
| Tissue Location | Ubiquitously expressed. Expression is down- regulated in a variety of tumor types including breast, colon, prostate and rectal tumors, and is up-regulated in certain hepatic carcinomas |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognise both human isoforms of this protein.
References
GCIP, a novel human grap2 and cyclin D interacting protein, regulates E2F-mediated transcriptional activity. Xia C, Bao Z, Tabassam F, Ma W, Qiu M, Hua S, Liu M. J Biol Chem. 2000 Jul 7;275(27):20942-8. PMID: 10801854
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