|Application ||FC, E|
|Other Accession||NP_001073289.1, NP_004886.3, NP_899632.1, NP_001120933.1, NP_001120934.1, 114548|
|Calculated MW||118173 Da|
|Other Names||NACHT, LRR and PYD domains-containing protein 3, Angiotensin/vasopressin receptor AII/AVP-like, Caterpiller protein 1.1, CLR1.1, Cold autoinflammatory syndrome 1 protein, Cryopyrin, PYRIN-containing APAF1-like protein 1, NLRP3, C1orf7, CIAS1, NALP3, PYPAF1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CIAS1 / cryopyrin ( C Terminus) Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||C1orf7, CIAS1, NALP3, PYPAF1|
|Function||May function as an inducer of apoptosis. Interacts selectively with ASC and this complex may function as an upstream activator of NF-kappa-B signaling. Inhibits TNF-alpha induced activation and nuclear translocation of RELA/NF-KB p65. Also inhibits transcriptional activity of RELA. Activates caspase-1 in response to a number of triggers including bacterial or viral infection which leads to processing and release of IL1B and IL18.|
|Tissue Location||Expressed in blood leukocytes. Strongly expressed in polymorphonuclear cells and osteoblasts. Undetectable or expressed at a lower magnitude in B- and T-lymphoblasts, respectively. High level of expression detected in chondrocytes Detected in non-keratinizing epithelia of oropharynx, esophagus and ectocervix and in the urothelial layer of the bladder|
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Provided below are standard protocols that you may find useful for product applications.
Variants (NP_001073289.1; NP_004886.3) encode the same isoform.
Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome. Hoffman HM, Mueller JL, Broide DH, Wanderer AA, Kolodner RD. Nat Genet. 2001 Nov;29(3):301-5. PMID: 11687797
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