|Other Accession||NP_055107.3, NP_065700.1, 23466, 57332|
|Predicted||Human, Mouse, Rat, Pig, Dog, Cow|
|Calculated MW||43898 Da|
|Other Names||Chromobox protein homolog 6, CBX6|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CBX6 and CBX8 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognise both the human proteins CBX6 and CBX8, which are almost identical.
HPC3 is a new human polycomb orthologue that interacts and associates with
RING1 and Bmi1 and has transcriptional repression properties. Bardos JI, Saurin AJ, Tissot C, Duprez E, Freemont PS. J Biol Chem. 2000 Sep 15;275(37):28785-92. PMID: 10825164
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