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ARIH2 / TRIAD1 Antibody (C-Term)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, IP, E |
|---|---|
| Primary Accession | O95376 |
| Other Accession | NP_006312.1, 10425, 23807 (mouse) |
| Reactivity | Human, Mouse |
| Predicted | Rat, Dog, Cow |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 57819 Da |
| Gene ID | 10425 |
|---|---|
| Other Names | E3 ubiquitin-protein ligase ARIH2, ARI-2, Protein ariadne-2 homolog, 6.3.2.-, Triad1 protein, ARIH2, ARI2, TRIAD1 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ARIH2 / TRIAD1 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ARIH2 |
|---|---|
| Synonyms | ARI2, TRIAD1 {ECO:0000303|PubMed:1611831 |
| Function | E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 (PubMed:16118314, PubMed:17646546, PubMed:19340006, PubMed:24076655). Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-5-RING ubiquitin ligase complex (ECS complex, also named CRL5 complex) and initiating ubiquitination of ECS substrates: associates with ECS complex and specifically mediates addition of the first ubiquitin on ECS targets (By similarity). The initial ubiquitin is then elongated (By similarity). E3 ubiquitin-protein ligase activity is activated upon binding to neddylated form of the ECS complex (PubMed:24076655). Mediates 'Lys-6', 'Lys-48'- and 'Lys-63'-linked polyubiquitination (PubMed:16118314, PubMed:17646546, PubMed:19340006). May play a role in myelopoiesis (PubMed:19340006). |
| Cellular Location | Nucleus. Cytoplasm |
| Tissue Location | Widely expressed with higher expression in granulocytes. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
TRIADs: a new class of proteins with a novel cysteine-rich signature. van der Reijden BA, Erpelinck-Verschueren CA, Lowenberg B, Jansen JH. Protein Sci. 1999 Jul;8(7):1557-61. PMID: 10422847
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