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SIGLECL1 Antibody (C-Term)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | Q96PQ1 |
| Other Accession | NP_201586.1, NP_443729.1, 89858 |
| Predicted | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 64984 Da |
| Gene ID | 89858 |
|---|---|
| Other Names | Sialic acid-binding Ig-like lectin 12, Siglec-12, Sialic acid-binding Ig-like lectin-like 1, Siglec-L1, SIGLEC12, SIGLECL1, SLG |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SIGLECL1 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SIGLEC12 |
|---|---|
| Synonyms | SIGLECL1, SLG |
| Function | Putative adhesion molecule that mediates sialic-acid dependent binding to cells. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. |
| Cellular Location | Membrane; Single-pass type I membrane protein. |
| Tissue Location | Isoform Short is highly expressed in spleen, small intestine and adrenal gland; it is lower expressed in thyroid, placenta, brain, stomach, bone marrow, spinal cord and breast. Isoform Long is highly expressed in spleen, small intestine and bone marrow; it is lower expressed in thyroid, placenta, thymus, trachea, stomach, lung, adrenal gland, fetal brain and testis |
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognise both human isoforms of this protein (NP_201586.1; NP_443729.1).
References
Identification and characterization of S2V, a novel putative siglec that contains two V set Ig-like domains and recruits protein-tyrosine phosphatases SHPs. Yu Z, Lai CM, Maoui M, Banville D, Shen SH. J Biol Chem. 2001 Jun 29;276(26):23816-24. PMID: 11328818
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