RNF13 / RZF (isoform 1 and 3) Antibody (C-Term)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC, E |
---|---|
Primary Accession | O43567 |
Other Accession | NP_009213.1, 11342 |
Reactivity | Human |
Predicted | Mouse, Rat, Pig, Dog, Cow |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 mg/ml |
Isotype | IgG |
Calculated MW | 42814 Da |
Gene ID | 11342 |
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Other Names | E3 ubiquitin-protein ligase RNF13, 6.3.2.-, RING finger protein 13, RNF13, RZF |
Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | RNF13 / RZF (isoform 1 and 3) Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | RNF13 {ECO:0000303|PubMed:18794910, ECO:0000312|HGNC:HGNC:10057} |
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Function | E3 ubiquitin-protein ligase that regulates cell proliferation (PubMed:18794910, PubMed:23378536, PubMed:30595371). Involved in apoptosis regulation (PubMed:23378536, PubMed:30595371). Mediates ER stress-induced activation of JNK signaling pathway and apoptosis by promoting ERN1 activation and splicing of XBP1 mRNA (PubMed:23378536, PubMed:30595371). Also involved in protein trafficking and localization (PubMed:24387786). |
Cellular Location | Endoplasmic reticulum membrane; Single-pass type I membrane protein. Late endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Nucleus inner membrane {ECO:0000250|UniProtKB:O54965}; Single-pass type I membrane protein. Note=Under certain conditions, relocalizes to recycling endosomes and to the inner nuclear membrane. {ECO:0000250|UniProtKB:O54965} |
Tissue Location | Widely expressed (at protein level). In normal pancreas, expressed in islets, but not in ducts, nor in acini (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Reported variants represent identical protein (NP_009213.1; NP_899237.1).
References
Identification and characterization of a RING zinc finger gene (C-RZF) expressed in chicken embryo cells. Tranque P, Crossin KL, Cirelli C, Edelman GM, Mauro VP. Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):3105-9. PMID: 8610176
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