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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > GERP / TRIM8 Antibody (C-Term)
GERP / TRIM8 Antibody (C-Term)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC, E |
|---|---|
| Primary Accession | Q9BZR9 |
| Other Accession | NP_112174.2, 81603, 93679 (mouse) |
| Reactivity | Human |
| Predicted | Mouse, Rat, Pig, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 61489 Da |
| Gene ID | 81603 |
|---|---|
| Other Names | Probable E3 ubiquitin-protein ligase TRIM8, 6.3.2.-, Glioblastoma-expressed RING finger protein, RING finger protein 27, Tripartite motif-containing protein 8, TRIM8, GERP, RNF27 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GERP / TRIM8 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TRIM8 |
|---|---|
| Synonyms | GERP, RNF27 |
| Function | E3 ubiquitin-protein ligase that participates in multiple biological processes including cell survival, differentiation, apoptosis, and in particular, the innate immune response (PubMed:27981609, PubMed:28747347). Participates in the activation of interferon-gamma signaling by promoting proteasomal degradation of the repressor SOCS1 (PubMed:12163497). Plays a positive role in the TNFalpha and IL-1beta signaling pathways. Mechanistically, induces the 'Lys-63'-linked polyubiquitination of MAP3K7/TAK1 component leading to the activation of NF-kappa-B (PubMed:22084099, PubMed:23152791, PubMed:27981609, PubMed:34871740). Modulates also STAT3 activity through negative regulation of PIAS3, either by degradation of PIAS3 through the ubiquitin-proteasome pathway or exclusion of PIAS3 from the nucleus (PubMed:20516148). Negatively regulates TLR3/4-mediated innate immune response by catalyzing 'Lys-6'- and 'Lys-33'-linked polyubiquitination of TICAM1 and thereby disrupting the TICAM1-TBK1 interaction (PubMed:28747347). |
| Cellular Location | Cytoplasm. Nucleus. Nucleus, nuclear body. Note=Nucleo-cytoplasmic translocation is involved in regulation of NF-kappa-B. |
| Tissue Location | Widely expressed. Expressed in glomerular podocytes of kidneys. {ECO:0000269|PubMed:33508234, ECO:0000305} |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
A novel RING finger-B box-coiled-coil protein, GERP. Vincent SR, Kwasnicka DA, Fretier P. Biochem Biophys Res Commun. 2000 Dec 20;279(2):482-6. PMID: 11118312
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$ 341.00
Cat# AF2319a
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