|Application ||IHC, E|
|Other Accession||NP_005870.2, 10293|
|Calculated MW||53294 Da|
|Other Names||E3 ubiquitin-protein ligase TRAIP, 6.3.2.-, RING finger protein 206, TRAF-interacting protein, TRAIP, RNF206, TRIP|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TRIP / TRAIP Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Inhibits activation of NF-kappa-B mediated by TNF (By similarity). Negatively regulates TLR3/4- and RIG-I-mediated IRF3 activation and subsequent IFN-beta production and cellular antiviral response by promoting 'Lys-48'-linked polyubiquitination of TNK1 leading to its proteasomal degradation. May mediate assembly of 'Lys-63'-linked poly-ubiquitin chains on the Y-family polymerase POLN to facilitate bypass of DNA lesions and preserve genomic integrity.|
|Cellular Location||Cytoplasm. Cytoplasm, perinuclear region. Nucleus, nucleolus. Note=Occasionally observed at nuclear puncta|
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Provided below are standard protocols that you may find useful for product applications.
TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation. Lee SY, Lee SY, Choi Y. J Exp Med. 1997 Apr 7;185(7):1275-85. PMID: 9104814
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