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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > JIP3 / Syd2 / JSAP1 Antibody (N-Term)
JIP3 / Syd2 / JSAP1 Antibody (N-Term)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC, E |
|---|---|
| Primary Accession | Q9UPT6 |
| Other Accession | NP_055948.2, NP_001035529.1, 23162, 30957 (mouse) |
| Reactivity | Mouse |
| Predicted | Human, Rat, Cow |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 147457 Da |
| Gene ID | 23162 |
|---|---|
| Other Names | C-Jun-amino-terminal kinase-interacting protein 3, JIP-3, JNK-interacting protein 3, JNK MAP kinase scaffold protein 3, Mitogen-activated protein kinase 8-interacting protein 3, MAPK8IP3, JIP3, KIAA1066 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | JIP3 / Syd2 / JSAP1 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MAPK8IP3 |
|---|---|
| Synonyms | JIP3, KIAA1066 |
| Function | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:12189133). May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). Promotes neuronal axon elongation in a kinesin- and JNK-dependent manner. Activates cofilin at axon tips via local activation of JNK, thereby regulating filopodial dynamics and enhancing axon elongation. Its binding to kinesin heavy chains (KHC), promotes kinesin-1 motility along microtubules and is essential for axon elongation and regeneration. Regulates cortical neuronal migration by mediating NTRK2/TRKB anterograde axonal transport during brain development (By similarity). Acts as an adapter that bridges the interaction between NTRK2/TRKB and KLC1 and drives NTRK2/TRKB axonal but not dendritic anterograde transport, which is essential for subsequent BDNF-triggered signaling and filopodia formation (PubMed:21775604). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q9ESN9}. Golgi apparatus {ECO:0000250|UniProtKB:Q9ESN9}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q9ESN9}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q9ESN9}. Cell projection, axon {ECO:0000250|UniProtKB:E9PSK7}. Cell projection, dendrite {ECO:0000250|UniProtKB:E9PSK7}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:E9PSK7}. Note=Localized in the soma and growth cones of differentiated neurites and the Golgi and vesicles of the early secretory compartment of epithelial cells. KIF5A/B/C-mediated transportation to axon tips is essential for its function in enhancing neuronal axon elongation. {ECO:0000250|UniProtKB:E9PSK7, ECO:0000250|UniProtKB:Q9ESN9} |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognise both reported Human isoforms of this protein (as represented by NP_055948.2 and NP_001035529.1).
References
Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3. Kelkar N, Gupta S, Dickens M, Davis RJ. Mol Cell Biol. 2000 Feb;20(3):1030-43. PMID: 10629060
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$ 341.00
Cat# AF2338a
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