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USP16 / UBP-M Antibody (N-Term)

Peptide-affinity purified goat antibody

     
  • IHC - USP16 / UBP-M Antibody (N-Term) AF2343a
    AF2343a (4 µg/ml) staining of paraffin embedded Human Human Kidney. Steamed antigen retrieval with Tris/EDTA buffer pH 9, HRP-staining.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC, E
Primary Accession Q9Y5T5
Other Accession NP_006438.1, NP_001001992.1, 10600
Reactivity Human
Predicted Mouse, Rat, Pig, Dog, Cow
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 93570 Da
Additional Information
Gene ID 10600
Other Names Ubiquitin carboxyl-terminal hydrolase 16 {ECO:0000255|HAMAP-Rule:MF_03062}, 3.4.19.12 {ECO:0000255|HAMAP-Rule:MF_03062}, Deubiquitinating enzyme 16 {ECO:0000255|HAMAP-Rule:MF_03062}, Ubiquitin thioesterase 16 {ECO:0000255|HAMAP-Rule:MF_03062}, Ubiquitin-processing protease UBP-M, Ubiquitin-specific-processing protease 16 {ECO:0000255|HAMAP-Rule:MF_03062}, USP16 {ECO:0000255|HAMAP-Rule:MF_03062}
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsUSP16 / UBP-M Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name USP16 {ECO:0000255|HAMAP-Rule:MF_03062}
Function Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator (PubMed:17914355). Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser- 11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis (PubMed:17914355). In resting B- and T- lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination (PubMed:17914355). Prefers nucleosomal substrates (PubMed:17914355). Does not deubiquitinate histone H2B (PubMed:17914355). Also deubiquitinates non- histone proteins, such as ribosomal protein RPS27A: deubiquitination of monoubiquitinated RPS27A promotes maturation of the 40S ribosomal subunit (PubMed:32129764).
Cellular Location Nucleus. Cytoplasm
Tissue Location Present in all the tissues examined including fetal brain, lung, liver, kidney, and adult heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas
Research Areas
Citations (0)
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Background

This antibody is expected to recognise isoform a (NP_006438.1) and isoform b (NP_001001992.1). Reported variants represent identical protein (NP_006438.1; NP_001027582.1).

References

A mutant deubiquitinating enzyme (Ubp-M) associates with mitotic chromosomes and blocks cell division. Cai SY, Babbitt RW, Marchesi VT. Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):2828-33. PMID: 10077596

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$ 341.00
Cat# AF2343a
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