|Other Accession||NP_060215.4, NP_001116855.1, NP_001116856.1, NP_001116857.1, 54880, 71458 (mouse)|
|Predicted||Human, Mouse, Pig, Dog, Cow|
|Calculated MW||192189 Da|
|Other Names||BCL-6 corepressor, BCoR, BCOR, KIAA1575|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||BCOR / BCL6 co-repressor Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence- specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2).|
|Tissue Location||Ubiquitously expressed.|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognise all reported isoforms. Variants (NP_060215.4; NP_001116855.1) encode the same isoform.
The forkhead transcription factor AFX activates apoptosis by induction of the BCL-6 transcriptional repressor. Tang TT, Dowbenko D, Jackson A, Toney L, Lewin DA, Dent AL, Lasky LA. J Biol Chem. 2002 Apr 19;277(16):14255-65. Epub 2002 Jan 02. PMID: 11777915
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