FBXL12 Antibody (C-Term)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC, Pep-ELISA |
---|---|
Primary Accession | Q9NXK8 |
Other Accession | NP_060173.1, 54850, 30843 (mouse) |
Reactivity | Human |
Predicted | Mouse, Rat, Dog |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 mg/ml |
Isotype | IgG |
Calculated MW | 37026 Da |
Gene ID | 54850 |
---|---|
Other Names | F-box/LRR-repeat protein 12, F-box and leucine-rich repeat protein 12, F-box protein FBL12, FBXL12, FBL12 |
Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | FBXL12 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | FBXL12 |
---|---|
Synonyms | FBL12 |
Function | Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia. |
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Provided below are standard protocols that you may find useful for product applications.
References
A family of mammalian F-box proteins. Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW. Curr Biol. 1999 Oct 21;9(20):1180-2. PMID: 10531037
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