|Application ||WB, E|
|Other Accession||NP_036228.1, 26060|
|Calculated MW||79663 Da|
|Other Names||DCC-interacting protein 13-alpha, Dip13-alpha, Adapter protein containing PH domain, PTB domain and leucine zipper motif 1, APPL1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||APPL / DIP13alpha Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction.|
|Cellular Location||Early endosome membrane; Peripheral membrane protein. Nucleus. Note=Early endosomal membrane-bound and nuclear Translocated into the nucleus upon release from endosomal membranes following internalization of EGF|
|Tissue Location||High levels in heart, ovary, pancreas and skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2. Mitsuuchi Y, Johnson SW, Sonoda G, Tanno S, Golemis EA, Testa JR. Oncogene. 1999 Sep 2;18(35):4891-8. PMID: 10490823
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