|Application ||WB, IHC, E|
|Other Accession||NP_006782.1, NP_996670.1, 10933, 21761 (mouse)|
|Predicted||Human, Rat, Pig, Cow|
|Calculated MW||41474 Da|
|Other Names||Mortality factor 4-like protein 1, MORF-related gene 15 protein, Protein MSL3-1, Transcription factor-like protein MRG15, MORF4L1, MRG15|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MRG15 / MORF4L1 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci.|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognise isoform 1 (NP_006782.1) and isoform 2 (NP_996670.1).
MRG15, a Novel Chromodomain Protein, Is Present in Two Distinct Multiprotein Complexes Involved in Transcriptional Activation. Pardo PS, Leung JK, Lucchesi JC, Pereira-Smith OM. J Biol Chem. 2002 Dec 27;277(52):50860-6. PMID: 12397079
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