|Other Accession||NP_005490, 10054, 50995 (mouse)|
|Calculated MW||71224 Da|
|Other Names||SUMO-activating enzyme subunit 2, 6.3.2.-, Anthracycline-associated resistance ARX, Ubiquitin-like 1-activating enzyme E1B, Ubiquitin-like modifier-activating enzyme 2, UBA2, SAE2, UBLE1B|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SAE2 / UBA2 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.|
|Cellular Location||Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and the nucleus, sumoylation is required either for nuclear translocation or nuclear retention|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1. Desterro JM, Rodriguez MS, Kemp GD, Hay RT. J Biol Chem. 1999 Apr 9;274(15):10618-24. PMID: 10187858
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