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CENTD2 / ARAP1 Antibody (C-Term)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
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- BACKGROUND
Application 
| WB, ICC, E |
|---|---|
| Primary Accession | Q96P48 |
| Other Accession | NP_056057.2, NP_001035207.1, NP_001128662.1, 116985, 69710 (mouse) |
| Reactivity | Mouse |
| Predicted | Human, Rat, Pig, Dog, Cow |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 162192 Da |
| Gene ID | 116985 |
|---|---|
| Other Names | Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1, Centaurin-delta-2, Cnt-d2, ARAP1, CENTD2, KIAA0782 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CENTD2 / ARAP1 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ARAP1 |
|---|---|
| Synonyms | CENTD2, KIAA0782 |
| Function | Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase- activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Has a preference for ARF1 and ARF5 (By similarity). |
| Cellular Location | Cytoplasm. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Cell membrane. Note=Associated with Golgi stacks in resting cells. Throughout the cytoplasm and in surface protrusion in cells that are in the process of attaching to a surface and spreading |
| Tissue Location | Detected in heart, skeletal muscle, spleen, kidney, liver, placenta, lung, peripheral blood leukocytes, adrenal gland, bone marrow, brain, lymph node, mammary gland, prostate, spinal cord, stomach, thyroid and trachea. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognise isoform a (NP_056057.2), isoform c (NP_001035207.1) and isoform d (NP_001128662.1).
References
ARAP1: a point of convergence for Arf and Rho signaling. Miura K, Jacques KM, Stauffer S, Kubosaki A, Zhu K, Hirsch DS, Resau J, Zheng Y, Randazzo PA. Mol Cell. 2002 Jan;9(1):109-19. PMID: 11804590
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