|Application ||WB, ICC, E|
|Other Accession||NP_056057.2, NP_001035207.1, NP_001128662.1, 116985, 69710 (mouse)|
|Predicted||Human, Rat, Pig, Dog, Cow|
|Calculated MW||162192 Da|
|Other Names||Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1, Centaurin-delta-2, Cnt-d2, ARAP1, CENTD2, KIAA0782|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CENTD2 / ARAP1 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Has a preference for ARF1 and ARF5 (By similarity).|
|Cellular Location||Cytoplasm. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Cell membrane Note=Associated with Golgi stacks in resting cells. Throughout the cytoplasm and in surface protrusion in cells that are in the process of attaching to a surface and spreading|
|Tissue Location||Detected in heart, skeletal muscle, spleen, kidney, liver, placenta, lung, peripheral blood leukocytes, adrenal gland, bone marrow, brain, lymph node, mammary gland, prostate, spinal cord, stomach, thyroid and trachea|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognise isoform a (NP_056057.2), isoform c (NP_001035207.1) and isoform d (NP_001128662.1).
ARAP1: a point of convergence for Arf and Rho signaling. Miura K, Jacques KM, Stauffer S, Kubosaki A, Zhu K, Hirsch DS, Resau J, Zheng Y, Randazzo PA. Mol Cell. 2002 Jan;9(1):109-19. PMID: 11804590
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