|Other Accession||NP_005757.1, NP_001001715.2, 10160|
|Predicted||Human, Mouse, Rat, Cow|
|Calculated MW||118633 Da|
|Other Names||FERM, RhoGEF and pleckstrin domain-containing protein 1, Chondrocyte-derived ezrin-like protein, Pleckstrin homology domain-containing family C member 2, PH domain-containing family C member 2, FARP1, CDEP, PLEKHC2|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CDEP / FARP1 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity).|
|Cellular Location||Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse. Cell junction, synapse, synaptosome. Cytoplasm, cytosol. Cell projection, filopodium. Cell projection, dendrite. Cell projection, dendritic spine Note=Recruited to the cell membrane via interaction with CADM1|
|Tissue Location||Detected in cAMP-treated chondrocytes, but not in untreated chondrocytes. Detected in fetal brain, heart and spleen, and in adult testis, kidney and lung|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognise isoform 1 (NP_005757.1) and isoform 2 (NP_001001715.2).
Molecular cloning and characterization of CDEP, a novel human protein containing the ezrin-like domain of the band 4.1 superfamily and the Dbl homology domain of Rho guanine nucleotide exchange factors. Koyano Y, Kawamoto T, Shen M, Yan W, Noshiro M, Fujii K, Kato Y. Biochem Biophys Res Commun. 1997 Dec 18;241(2):369-75. PMID: 9425278
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