|Application ||ICC, E|
|Other Accession||NP_006295.1, 7979, 20422 (mouse)|
|Predicted||Human, Mouse, Pig, Dog, Cow|
|Calculated MW||8278 Da|
|Other Names||26S proteasome complex subunit DSS1, Deleted in split hand/split foot protein 1, Split hand/foot deleted protein 1, Split hand/foot malformation type 1 protein, SHFM1, DSS1, SHFDG1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DSS1 / SHFM1 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Subunit of the 26S proteasome which plays a role in ubiquitin-dependent proteolysis (PubMed:15117943). Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3 (PubMed:22307388). The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and thus transcription- associated genomic instability. R-loop accumulation increases in DSS1-depleted cells.|
|Tissue Location||Expressed in limb bud, craniofacial primordia and skin|
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Identification of Dss1 as a 12-O-Tetradecanoylphorbol-13-acetate-responsive Gene Expressed in Keratinocyte Progenitor Cells, with Possible Involvement in Early Skin Tumorigenesis. Wei SJ, Trempus CS, Cannon RE, Bortner CD, Tennant RW. J Biol Chem. 2003 Jan 17;278(3):1758-68. PMID: 12419822
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