|Other Accession||NP_036433.2, 9863|
|Calculated MW||158754 Da|
|Other Names||Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2, Atrophin-1-interacting protein 1, AIP-1, Atrophin-1-interacting protein A, Membrane-associated guanylate kinase inverted 2, MAGI-2, MAGI2, ACVRINP1, AIP1, KIAA0705|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||AIP1 / MAGI2 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||ACVRINP1, AIP1, KIAA0705|
|Function||Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth.|
|Cellular Location||Cytoplasm. Late endosome. Cell junction, synapse, synaptosome Cell membrane; Peripheral membrane protein. Note=Localized diffusely in the cytoplasm before nerve growth factor (NGF) stimulation. Recruted to late endosomes after NGF stimulation. Membrane-associated in synaptosomes (By similarity).|
|Tissue Location||Specifically expressed in brain.|
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Provided below are standard protocols that you may find useful for product applications.
Identification and characterization of a PDZ protein that interacts with activin type II receptors. Shoji H, Tsuchida K, Kishi H, Yamakawa N, Matsuzaki T, Liu Z, Nakamura T, Sugino H. J Biol Chem. 2000 Feb 25;275(8):5485-92. PMID: 10681527
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