AIP1 / MAGI2 Antibody (C-Term)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| E |
---|---|
Primary Accession | Q86UL8 |
Other Accession | NP_036433.2, 9863 |
Predicted | Human |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 mg/ml |
Isotype | IgG |
Calculated MW | 158754 Da |
Gene ID | 9863 |
---|---|
Other Names | Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2, Atrophin-1-interacting protein 1, AIP-1, Atrophin-1-interacting protein A, Membrane-associated guanylate kinase inverted 2, MAGI-2, MAGI2, ACVRINP1, AIP1, KIAA0705 |
Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | AIP1 / MAGI2 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | MAGI2 |
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Synonyms | ACVRINP1, AIP1, KIAA0705 |
Function | Seems to act as a scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins (By similarity). Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth (By similarity). May play a role in regulating activin-mediated signaling in neuronal cells (By similarity). Enhances the ability of PTEN to suppress AKT1 activation (PubMed:10760291). Plays a role in receptor- mediated clathrin-dependent endocytosis which is required for ciliogenesis (By similarity). |
Cellular Location | Cytoplasm. Late endosome. Synapse, synaptosome. Cell membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q9WVQ1}. Cell projection, cilium {ECO:0000250|UniProtKB:Q9WVQ1}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q9WVQ1}. Photoreceptor inner segment {ECO:0000250|UniProtKB:Q9WVQ1}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:Q9WVQ1}. Note=Localized diffusely in the cytoplasm before nerve growth factor (NGF) stimulation Recruited to late endosomes after NGF stimulation. Membrane-associated in synaptosomes (By similarity). |
Tissue Location | Specifically expressed in brain. |
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Provided below are standard protocols that you may find useful for product applications.
References
Identification and characterization of a PDZ protein that interacts with activin type II receptors. Shoji H, Tsuchida K, Kishi H, Yamakawa N, Matsuzaki T, Liu Z, Nakamura T, Sugino H. J Biol Chem. 2000 Feb 25;275(8):5485-92. PMID: 10681527
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