|Application ||IHC, E|
|Other Accession||NP_001640, 357|
|Calculated MW||176410 Da|
|Other Names||Protein Shroom2, Apical-like protein, Protein APXL, SHROOM2, APXL|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||APXL Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity).|
|Cellular Location||Apical cell membrane. Cell junction, tight junction. Cytoplasm, cytoskeleton. Note=Associates with cortical F-actin|
|Tissue Location||Abundant in retina and melanoma; also in brain, placenta, lung, kidney and pancreas|
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Provided below are standard protocols that you may find useful for product applications.
Cloning of a human homologue of the Xenopus laevis APX gene from the ocular albinism type 1 critical region. Schiaffino MV, Bassi MT, Rugarli EI, Renieri A, Galli L, Ballabio A. Hum Mol Genet. 1995 Mar;4(3):373-82. PMID: 7795590
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