MDG1 / DNAJB9 Antibody (C-Term)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC, E |
---|---|
Primary Accession | Q9UBS3 |
Other Accession | NP_036460.1, 4189, 27362 (mouse), 24908 (rat) |
Reactivity | Human |
Predicted | Mouse, Rat, Dog, Cow |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 mg/ml |
Isotype | IgG |
Calculated MW | 25518 Da |
Gene ID | 4189 |
---|---|
Other Names | DnaJ homolog subfamily B member 9, Endoplasmic reticulum DNA J domain-containing protein 4, ER-resident protein ERdj4, ERdj4, Microvascular endothelial differentiation gene 1 protein, Mdg-1, DNAJB9, MDG1 |
Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | MDG1 / DNAJB9 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | DNAJB9 |
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Synonyms | MDG1 {ECO:0000303|Ref.1} |
Function | Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (By similarity). J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins (PubMed:18400946). In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1 (By similarity). Also involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Required for survival of B- cell progenitors and normal antibody production (By similarity). |
Cellular Location | Endoplasmic reticulum lumen {ECO:0000250|UniProtKB:Q9QYI6} |
Tissue Location | Widely expressed. Expressed at highest level in the liver, placenta and kidney (PubMed:11836248) |
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Provided below are standard protocols that you may find useful for product applications.
References
Assignment of the microvascular endothelial differentiation gene 1 (MDG1) to human chromosome band 14q24.2-->q24.3 by fluorescence in situ hybridization. Prols F, Liehr T, Rinke R, Rautenstrauss B. Cytogenet Cell Genet. 1997;79(1-2):149-50. No abstract available. PMID: 9533036
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