|Application ||WB, E|
|Other Accession||NP_009133.2, 11216, 56697 (mouse)|
|Predicted||Mouse, Rat, Dog|
|Calculated MW||73818 Da|
|Other Names||A-kinase anchor protein 10, mitochondrial, AKAP-10, Dual specificity A kinase-anchoring protein 2, D-AKAP-2, Protein kinase A-anchoring protein 10, PRKA10, AKAP10|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||AKAP10 / D-AKAP2 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase (By similarity).|
|Cellular Location||Mitochondrion. Membrane. Cytoplasm. Note=Predominantly mitochondrial but also membrane associated and cytoplasmic|
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Provided below are standard protocols that you may find useful for product applications.
D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain. Huang LJ, Durick K, Weiner JA, Chun J, Taylor SS. Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11184-9. PMID: 9326583
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