|Application ||IHC, E|
|Other Accession||NP_065881.1, 57590|
|Calculated MW||46324 Da|
|Other Names||WD repeat and FYVE domain-containing protein 1, FENS-1, Phosphoinositide-binding protein 1, WD40- and FYVE domain-containing protein 1, Zinc finger FYVE domain-containing protein 17, WDFY1, KIAA1435, WDF1, ZFYVE17|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FENS1 / WDFY1 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIAA1435, WDF1, ZFYVE17|
|Function||Positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1. Promotes TLR3/4 ligand-induced activation of transcription factors IRF3 and NF-kappa-B, as well as the production of IFN-beta and inflammatory cytokines (PubMed:25736436).|
|Cellular Location||Early endosome|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognise both reported isoforms (as represented by NP_065881 and NP_848127)
FENS-1 and DFCP1 are FYVE domain-containing proteins with distinct functions in the endosomal and Golgi compartments. Ridley SH, Ktistakis N, Davidson K, Anderson KE, Manifava M, Ellson CD, Lipp P, Bootman M, Coadwell J, Nazarian A, Erdjument-Bromage H, Tempst P, Cooper MA, Thuring JW, Lim ZY, Holmes AB, Stephens LR, Hawkins PT. J Cell Sci. 2001 Nov;114(Pt 22):3991-4000. PMID: 11739631
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