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Cdc42-binding kinase alpha Antibody (N-Term)

Peptide-affinity purified goat antibody

  • IHC - Cdc42-binding kinase alpha Antibody (N-Term) AF2407a
    AF2407a (3.8 µg/ml) staining of paraffin embedded Human Cerebellum Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q5VT25
Other Accession NP_055641.3, NP_003598.2, 8476, 226751 (mouse), 114116 (rat)
Reactivity Human
Predicted Mouse, Rat, Dog, Cow
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 197307 Da
Additional Information
Gene ID 8476
Other Names Serine/threonine-protein kinase MRCK alpha,, CDC42-binding protein kinase alpha, DMPK-like alpha, Myotonic dystrophy kinase-related CDC42-binding kinase alpha, MRCK alpha, Myotonic dystrophy protein kinase-like alpha, CDC42BPA {ECO:0000312|EMBL:CAH71336.1}, KIAA0451
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCdc42-binding kinase alpha Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CDC42BPA {ECO:0000312|EMBL:CAH71336.1}
Synonyms KIAA0451
Function Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates: PPP1R12A, LIMK1 and LIMK2. May play a role in TFRC-mediated iron uptake.
Cellular Location Cytoplasm. Note=Displays a dispersed punctate distribution and concentrates along the cell periphery, especially at the leading edge and cell-cell junction This concentration is PH-domain dependent (By similarity)
Tissue Location Abundant in the heart, brain, skeletal muscle, kidney, and pancreas, with little or no expression in the lung and liver.
Research Areas
Citations (0)

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This antibody is expected to recognise both reported Human isoforms (NP_055641.3 and NP_003598.2).


Cloning and chromosomal location of a novel member of the myotonic dystrophy family of protein kinases. Zhao Y, Loyer P, Li H, Valentine V, Kidd V, Kraft AS. J Biol Chem. 1997 Apr 11;272(15):10013-20. PMID: 9092543

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$ 325.00
Cat# AF2407a
(40 western blots)
Availability: 7-10 days
Bulk Size
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